Isoguvacine hydrochloride

Research use only, not for human use.

Isoguvacine hydrochloride is a GABA receptor agonist. Isoguvacine hydrochloride binds to rat synaptic cortical membranes and activates α1β2γ2S, α2β2γ2S, α3β2γ2S, α5β2γ2S, and ρ1 subunit GABAA receptors.

Isoguvacine hydrochloride is a GABA receptor agonist. Isoguvacine hydrochloride binds to rat synaptic cortical membranes and activates α1β2γ2S, α2β2γ2S, α3β2γ2S, α5β2γ2S, and ρ1 subunit GABAA receptors.(In Vitro):Treatment of 50 μM Isoguvacine to block epileptiform events in 2 of 6 organotypic hippocampal slice cultures, Isoguvacine dose-dependently inhibits hypomagnesium-induced epileptiform events. Isoguvacine binds to mouse forebrain synaptic membrane preparations and can specifically bind to GABA, muscimol and bicuculline, but not picrotoxin or diaminobutyric acid. The highest levels of binding are observed in the cerebellum, cortex and hippocampus.

1,2,3,6-tetrahydro-4-pyridinecarboxylic acid hydrochloride

Others

Other Targets

NR2B-NMDA

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68547-97-7

163.6

C6H10ClNO2

>98% (HPLC)

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Cl.OC(=O)C1=CCNCC1

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(-20℃)

With Ice Pack

≥ 2 years