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Isoguvacine hydrochloride
CAS No. 68547-97-7
Isoguvacine hydrochloride ( 1,2,3,6-tetrahydro-4-pyridinecarboxylic acid hydrochloride )
Catalog No. M26261 CAS No. 68547-97-7
Isoguvacine hydrochloride is a GABA receptor agonist. Isoguvacine hydrochloride binds to rat synaptic cortical membranes and activates α1β2γ2S, α2β2γ2S, α3β2γ2S, α5β2γ2S, and ρ1 subunit GABAA receptors.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 25MG | 51 | In Stock |
|
| 50MG | 86 | In Stock |
|
| 100MG | 132 | In Stock |
|
| 500MG | 332 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameIsoguvacine hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionIsoguvacine hydrochloride is a GABA receptor agonist. Isoguvacine hydrochloride binds to rat synaptic cortical membranes and activates α1β2γ2S, α2β2γ2S, α3β2γ2S, α5β2γ2S, and ρ1 subunit GABAA receptors.
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DescriptionIsoguvacine hydrochloride is a GABA receptor agonist. Isoguvacine hydrochloride binds to rat synaptic cortical membranes and activates α1β2γ2S, α2β2γ2S, α3β2γ2S, α5β2γ2S, and ρ1 subunit GABAA receptors.(In Vitro):Treatment of 50 μM Isoguvacine to block epileptiform events in 2 of 6 organotypic hippocampal slice cultures, Isoguvacine dose-dependently inhibits hypomagnesium-induced epileptiform events. Isoguvacine binds to mouse forebrain synaptic membrane preparations and can specifically bind to GABA, muscimol and bicuculline, but not picrotoxin or diaminobutyric acid. The highest levels of binding are observed in the cerebellum, cortex and hippocampus.
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Synonyms1,2,3,6-tetrahydro-4-pyridinecarboxylic acid hydrochloride
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PathwayOthers
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TargetOther Targets
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RecptorNR2B-NMDA
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Research Area——
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Indication——
Chemical Information
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CAS Number68547-97-7
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Formula Weight163.6
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Molecular FormulaC6H10ClNO2
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Purity>98% (HPLC)
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Solubility——
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SMILESCl.OC(=O)C1=CCNCC1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Ruslan I Stanika, et al. Coupling diverse routes of calcium entry to mitochondrial dysfunction and glutamate excitotoxicity. Proc Natl Acad Sci U S A. 2009 Jun 16;106(24):9854-9.
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